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Catabolite Activator Protein (blue) bound to a piece of DNA (red). In cell biology, catabolite activator protein (CAP), which is also known as cAMP receptor protein (CRP), is a trans-acting transcriptional activator in bacteria that effectively catalyzes the initiation of DNA transcription by interacting with RNA polymerase in a way that causes the DNA to bend.
In 2013, Batut et al. [13] combined CAP trapper, template switching, and 5′-phosphate-dependent exonuclease digestion in RAMPAGE to maximize promoter specificity. In 2014, Murata et al. [14] published the nAnTi-CAGE protocol, where capped 5′ ends are sequenced on the Illumina platform with no PCR amplification and no tag cleavage.
Molecular & Cellular Proteomics is a monthly peer-reviewed scientific journal established in 2002 and published by the American Society for Biochemistry and Molecular Biology. [1] It covers research on structural and functional properties of proteins , especially with regard to development.
One can think of molecular docking as a problem of “lock-and-key”, in which one wants to find the correct relative orientation of the “key” which will open up the “lock” (where on the surface of the lock is the key hole, which direction to turn the key after it is inserted, etc.).
When molecules on the surface of a motile eukaryotic cell are crosslinked, they are moved to one end of the cell to form a "cap".This phenomenon, the process of which is called cap formation, was discovered in 1971 on lymphocytes [1] and is a property of amoebae and all locomotory animal cells except sperm.
Structure-based virtual screening approach includes different computational techniques that consider the structure of the receptor that is the molecular target of the investigated active ligands. Some of these techniques include molecular docking, structure-based pharmacophore prediction, and molecular dynamics simulations.
Most pages in SCOP contain a search box. Entering "trypsin +human" retrieves several proteins, including the protein trypsinogen from humans. Selecting that entry displays a page that includes the "lineage", which is at the top of most SCOP pages. Human trypsonogen [check spelling] lineage. Root: scop; Class: All beta proteins [48724]
The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 29 member states, two prospect member states, and one associate member state. [2] EMBL was created in 1974 and is funded by public research money from its member states. [3]