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CHS is a paradoxical syndrome characterized by hyperemesis (persistent vomiting), as opposed to the better known antiemetic properties of cannabinoids. [15] The most prominent CHS symptoms are cyclical nausea, vomiting, and abdominal pain, concomitant with chronic cannabinoid use. [15]
Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brain's neurons. Positron emission tomography (PET) studies, have demonstrated that aprepitant can cross the blood brain barrier and bind to NK 1 receptors in the human brain. [ 10 ]
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer. They may be used for severe cases of gastroenteritis, especially if the patient is dehydrated. [1] [2]
Please go to the hyperemesis gravidarum talk page if you have an opinion about whether cannabinoids can or should be mentioned in that article's subsection for related to antiemetic medicines. (Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy.) Medical marijuana was first mentioned in the article in 2007 but a small ...
Laboratory experiments have suggested that cannabis and cannabinoids have anticarcinogenic and antitumor effects, [22] including a potential effect on breast- and lung-cancer cells. [23] While cannabis may have potential for refractory cancer pain or use as an antiemetic, much of the evidence comes from outdated or small studies, or animal ...
Hyperemesis gravidarum (HG) is a pregnancy complication that is characterized by severe nausea, vomiting, weight loss, and possibly dehydration. [1] Feeling faint may also occur. [ 2 ] It is considered a more severe form of morning sickness . [ 2 ]
Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. [1] [2] It mimics tetrahydrocannabinol (THC), the primary psychoactive compound found naturally occurring in Cannabis.
It is commonly used postoperatively as an antiemetic. The antiemetic activity increases with increased dosing; however, side effects also increase, which often limits maximal dosing. [13] For moderate to severe morning sickness and hyperemesis gravidarum: In the UK, Promethazine is the drug of first choice.