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Pyrantel is a medication used to treat a number of parasitic worm infections. [2] This includes ascariasis , hookworm infections , enterobiasis (pinworm infection), trichostrongyliasis , and trichinellosis . [ 2 ]
Praziquantel has a serum half-life of 0.8 to 1.5 hours in adults with normal renal and liver function. Metabolites have a half-life of 4 to 5 hours. In patients with significantly impaired liver function ( Child-Pugh score B and C), the serum half-life is increased to 3 to 8 hours.
Pyrantel pamoate – effective against most parasitic nematodes of the GIT; Macrocyclic lactones are glutamate-gated chloride channel agonists, [8] and include: Avermectins (including ivermectin and moxidectin) - effective against most common intestinal worms, except tapeworms, for which praziquantel is commonly used in conjunction for mass ...
Pyrantel pamoate (also called pyrantel embonate, brand names e.g., Reese's Pinworm Medicine, Pin-X, Combantrin, Anthel, Helmintox, and Helmex) kills adult pinworms through neuromuscular blockade, [27] and is considered as effective as the benzimidazole compounds and is used as a second-line medication. [9]
[24] [25] [26] Further testing confirmed aminorex in human and canine urine, meaning that both humans and dogs also metabolize levamisole into aminorex, [27] though it is unclear whether plasma aminorex is present at any appreciable level. Blood samples following oral administration of levamisole out to 172 hr post-dose did not demonstrate any ...
Drenching Merino hoggets, Walcha, NSW U.S. soldiers treating animals with de-worming medication in Eswatini during VETCAP. Deworming (sometimes known as worming, drenching or dehelmintization) is the giving of an anthelmintic drug (a wormer, dewormer, or drench) to a human or animals to rid them of helminths parasites, such as roundworm, flukes and tapeworm.
Ivermectin is highly effective even at the low dose of 100 μg per kg, and pyrantel is also effective at 25–50 mg per kg. [17] Benzimidazoles such as mebendazole, parbendazole and thiabendazole are also highly effective. [18]
In the package insert of a German pyrantel drug ("Helmex"), it says dosage is 10mg/kg, with one tablet containing 720mg of pyrantel embonate equivalent to 250mg of pure pyrantel. I will mark the passage with citation needed. --Victor--H 09:28, 19 July 2011 (UTC) Per Reese's insert, dosage is 11mg/ml for pyrantel base.