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Neuroplasticity is the process by which neurons adapt to a disturbance over time, and most often occurs in response to repeated exposure to stimuli. [27] Aerobic exercise increases the production of neurotrophic factors [note 1] (e.g., BDNF, IGF-1, VEGF) which mediate improvements in cognitive functions and various forms of memory by promoting blood vessel formation in the brain, adult ...
Paffenbarger's Harvard alumni health study, of 17,000 male alumni who graduated between 1916 and 1950, [1] found that when the alumni were in their forties, vigorous exercise predicted greater longevity and lower risk of cardiovascular disease, and that so long as energy expenditure was equivalent, it was irrelevant whether the exercise was ...
Subcutaneous administration of longevity factor α-klotho enhanced cognition in old rhesus macaques. [252] In a paywalled review, the authors of a heavily cited paper on the hallmarks of aging update the set of proposed hallmarks after a decade. [253] [254] A review with overlapping authors merge or link various hallmarks of cancer with those ...
Physical exercise results in numerous health benefits and is an important tool to combat obesity and its co-morbidities, including cardiovascular diseases. Exercise prevents both the onset and development of cardiovascular disease and is an important therapeutic tool to improve outcomes for patients with cardiovascular disease.
A 2009 review of longevity research noted: "Extrapolation from worms to mammals is risky at best, and it cannot be assumed that interventions will result in comparable life extension factors. Longevity gains from dietary restriction, or from mutations studied previously, yield smaller benefits to Drosophila than to nematodes, and smaller still ...
The term "calorie restriction" as used in the study of aging refers to dietary regimens that reduce calorie intake without incurring malnutrition. [1] If a restricted diet is not designed to include essential nutrients, malnutrition may result in serious deleterious effects, as shown in the Minnesota Starvation Experiment. [13]
Nathan Pritikin (August 29, 1915 – February 21, 1985) was an American inventor, engineer, nutritionist and longevity researcher. [1] [2] He promoted the Pritikin diet, a high-carbohydrate low-fat plant-based diet combined with regular aerobic exercise to prevent cardiovascular disease. [3]
"Healthspan, parental lifespan, and longevity are highly genetically correlated." [12]In July 2020 scientists, using public biological data on 1.75 m people with known lifespans overall, identify 10 genomic loci which appear to intrinsically influence healthspan, lifespan, and longevity – of which half have not been reported previously at genome-wide significance and most being associated ...