Search results
Results From The WOW.Com Content Network
Keratin (/ ˈ k ɛr ə t ɪ n / [1] [2]) is one of a family of structural fibrous proteins also known as scleroproteins. It is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin in vertebrates. Keratin also protects epithelial cells from damage or stress. Keratin is extremely ...
This central domain of the chain provides the molecular alignment in the keratin structure and makes the chains form coiled dimers in solution. The end-domain sequences of type I and II cytokeratin chains contain in both sides of the rod domain the subdomains V1 and V2, which have variable size and sequence.
Keratins belong to two types - acidic Type I and neutral-basic Type II, further categorized into Type I a and b, and Type II a and b. The initial step in forming keratin is the alignment of type I and type II keratin polypeptides to create a heterodimer, which then aggregates into higher-order structural units. [2]
[1] [2] These two groups of keratins were named as type I and type II keratins. [2] These two categories also represent the first two categories of the superfamily of intermediate filament proteins. Keratins in this table are classified in the first two columns according to the nomenclature established in 2006. [3]
This page was last edited on 31 December 2013, at 23:25 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
16678 Ensembl ENSG00000167768 ENSMUSG00000046834 UniProt P04264 P04104 RefSeq (mRNA) NM_006121 NM_008473 RefSeq (protein) NP_006112 NP_032499 Location (UCSC) Chr 12: 52.67 – 52.68 Mb Chr 15: 101.75 – 101.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Keratin 1 is a Type II intermediate filament (IFs) of the intracytoplasmatic cytoskeleton. Is co-expressed with and binds to ...
Alpha-keratin, or α-keratin, is a type of keratin found in mammalian vertebrates. This protein is the primary component in hairs , horns , claws , nails and the epidermis layer of the skin . α-keratin is a fibrous structural protein , meaning it is made up of amino acids that form a repeating secondary structure.
Keratin protein expression within the various layers and anatomic locations of the human integumentary system Keratin type Location of expression 1: Suprabasal epidermis of skin 2 (2e) Granular layer: 3: Cornea: 4: Suprabasal epidermis of mucosa 5: Basal layer: 6a: Suprabasal palmoplantar skin 6b: Basal palmoplantar skin Nail bed Hair follicle ...