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Nizatidine is a histamine H 2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. [2] It was patented in 1980 and approved for medical use in 1988. [3] [4] It was developed by Eli Lilly.
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia , although they have been surpassed in popularity by the more effective [ 1 ] proton pump inhibitors .
H 2 antagonists, which all end in "-tidine", are a type of antihistamine. In general usage, however, the term "antihistamine" typically refers to H 1 antagonists, which relieve allergic reactions. Like the H 1 antagonists, some H 2 antagonists function as inverse agonists rather than receptor antagonists, due to the constitutive activity of ...
Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. [4] It is taken by mouth or by injection into a vein. [4] It begins working within an ...
Maalox can be used as a standalone antacid treatment or in conjunction with prescription strength medication such as proton pump inhibitors and H2 blockers. Activists in the United States, the Czech Republic, Venezuela, and Turkey have reported using Maalox or other antacid solutions diluted with water as a home remedy for tear gas attacks. [6 ...
Since Tums is an over-the-counter drug, it is not considered a pharmaceutical-grade treatment (does not require a prescription). Prescription strength acid reflux medications often contain proton-pump inhibitors (PPI) or histamine H 2 receptor blockers (H 2 blockers, H 2 antagonists).
Cimetidine was first marketed in the United Kingdom in 1976, and in the U.S. in August 1977; therefore, it took 12 years from initiation of the H 2 receptor antagonist program to commercialization. By 1979, Tagamet was being sold in more than 100 countries and became the top-selling prescription product in the U.S., Canada, and several other ...
Clemastine is an antihistamine with anticholinergic and sedative effects. Antihistamines competitively bind to histamine receptor sites, thus reducing the neurotransmitter's effects. [9]