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An excipient is a substance formulated alongside the active ingredient of a medication.They may be used to enhance the active ingredient’s therapeutic properties; to facilitate drug absorption; to reduce viscosity; to enhance solubility; to improve long-term stabilization (preventing denaturation and aggregation during the expected shelf life); or to add bulk to solid formulations that have ...
Pharmaceutical formulation, in pharmaceutics, is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. The word formulation is often used in a way that includes dosage form .
Galenic formulation is named after Claudius Galen, a 2nd Century AD Greek physician, who codified the preparation of drugs using multiple ingredients. Today, galenic formulation is part of pharmaceutical formulation. The pharmaceutical formulation of a medicine affects the pharmacokinetics, pharmacodynamics and safety profile of a drug.
[5] [7] The solvent that is used as a dispersion medium can be aqueous, organic, inorganic, or a system of different solvents. [5] Topical gels are used as a contact or transport medium for active drugs to act on [4] or through the skin. [9] The active drug molecules are entwined into the 3D mesh of the gel and delivered to the site of action.
Pharmaceutical manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing can be broken down into a series of unit operations , such as milling , granulation , coating , tablet pressing , and others.
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Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.. Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone. [9]
Beginning with a mixture of polymer and solvent (top), cosolvents encourage the aggregation of polymers (right), simplifying production and improving performance. Without the use of cosolvent, droplets of primary solvent coalesce into distinct domains and polymer is more randomly dispersed (left). Adapted from Janssen et al (2015).