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  2. Blood–brain barrier - Wikipedia

    en.wikipedia.org/wiki/Bloodbrain_barrier

    The bloodbrain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood. [1]

  3. Drug delivery to the blood–brain barrier - Wikipedia

    en.wikipedia.org/wiki/Drug_delivery_to_the_brain

    The bloodbrain barrier is formed by special tight junctions between endothelial cells lining brain blood vessels. Blood vessels of all tissues contain this monolayer of endothelial cells, however only brain endothelial cells have tight junctions preventing passive diffusion of most substances into the brain tissue. [1]

  4. Biological barrier - Wikipedia

    en.wikipedia.org/wiki/Biological_barrier

    Blood-testis barrier, the biological barrier between blood and testes; Blood-placental barrier, the biological barrier between a pregnant individual's blood and foetal blood (blood of one or more foetuses) Blood-CSF barrier, the biological barrier between blood and cerebrospinal fluid (CSF; also called brain fluid) Blood–spinal cord barrier ...

  5. Ciprofloxacin - Wikipedia

    en.wikipedia.org/wiki/Ciprofloxacin

    Because Ciprofloxacin is lipophilic, it has the ability to cross the bloodbrain barrier. [61] The 2013 FDA label warns of nervous system effects. Ciprofloxacin, like other fluoroquinolones, is known to trigger seizures or lower the seizure threshold, and may cause other central nervous system adverse effects.

  6. Choroid plexus - Wikipedia

    en.wikipedia.org/wiki/Choroid_plexus

    The blood–cerebrospinal fluid barrier (BCSFB) is a fluid–brain barrier that is composed of a pair of membranes that separate blood from CSF at the capillary level and CSF from brain tissue. [14] The blood–CSF boundary at the choroid plexus is a membrane composed of epithelial cells and tight junctions that link them. [14] There is a CSF ...

  7. Glia limitans - Wikipedia

    en.wikipedia.org/wiki/Glia_limitans

    Within the brain, the glial limiting membrane is an important constituent of the bloodbrain barrier. Experiments using electron-dense markers have discovered that functional components of the bloodbrain barrier are the endothelial cells that compose the vessel itself.

  8. Blood–brain barrier disruption - Wikipedia

    en.wikipedia.org/wiki/Bloodbrain_barrier...

    The bloodbrain barrier (BBB) is protected by a network of blood vessels and tissue that shields it from harmful substances. This protection also stops anti-cancer drugs from getting to the brain. To treat brain tumours and other brain related diseases, [ 2 ] [ 3 ] bloodbrain barrier disruption is needed for the anti-cancer drugs to be ...

  9. Edwin Goldmann - Wikipedia

    en.wikipedia.org/wiki/Edwin_Goldmann

    Edwin Goldmann (12 November 1862 – 12 August 1913) was a biomedical researcher and surgeon most famous for his contributions in first characterizing the bloodbrain barrier. [ 1 ] Discovery of the bloodbrain barrier