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In the decomposition of taurine, it has been shown that molecular oxygen is activated by Iron II, which lies in the coordinating complex of taurine dioxygenase. [2] Here the enzyme with conjunction of an Iron II and 2-oxoglutarate maintain non-covalent bonds by electrostatic interactions, and coordinate a nucleophilic attack from dioxygen on 2-oxoglutarate carbon number 2. [3]
Taurine (/ ˈ t ɔː r iː n /), or 2-aminoethanesulfonic acid, is a non-proteinogenic naturally occurring amino sulfonic acid that is widely distributed in animal tissues. [1] It is a major constituent of bile and can be found in the large intestine, and accounts for up to 0.1% of total human body weight.
In enzymology, a taurine dehydrogenase (EC 1.4.99.2) is an enzyme that catalyzes the chemical reaction.. taurine + H 2 O + acceptor sulfoacetaldehyde + NH 3 + reduced acceptor. The 3 substrates of this enzyme are taurine, H 2 O, and acceptor, whereas its 3 products are sulfoacetaldehyde, NH 3, and reduced acceptor.
GitHub (/ ˈ ɡ ɪ t h ʌ b /) is a proprietary developer platform that allows developers to create, store, manage, and share their code. It uses Git to provide distributed version control and GitHub itself provides access control, bug tracking, software feature requests, task management, continuous integration, and wikis for every project. [8]
TauD is an alpha-ketoglutarate-dependent dioxygenase catalyzing the oxygenolytic release of sulfite from taurine. [1] The 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. (strain RASC) also belongs to this family. [ 2 ]
Generic structure of a taurate. R is an odd numbered alkyl group C n H 2n+1 with n = 7 – 17 carbon atoms.. Taurates (or taurides) are a group of mild anionic surfactants.They are composed of a hydrophilic head group, consisting of N-methyltaurine (2-methylaminoethanesulfonic acid) and a lipophilic residue, consisting of a long-chain carboxylic acid (fatty acid), both linked via an amide bond.
In eukaryotes, there are only 21 proteinogenic amino acids, the 20 of the standard genetic code, plus selenocysteine. Humans can synthesize 12 of these from each other or from other molecules of intermediary metabolism. The other nine must be consumed (usually as their protein derivatives), and so they are called essential amino acids.
UDCA and its taurine conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears. [1] [3] Ursodeoxycholic acid and tauroursodeoxycholic acid were first chemically synthesized in 1954 in Japan. [1] Ursodeoxycholic acid is produced in several countries for the treatment of gallstones and primary biliary ...