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Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. [4] Neutrophils make up the majority of circulating white blood cells and serve as the primary defense against infections by destroying bacteria, bacterial fragments and immunoglobulin-bound viruses in the blood. [5]
It most commonly affects individuals over the age of 65, due to the accumulation of genetic mutations that occur over time. [3] [18] CLL is rarely seen in individuals less than 40 years old. [19] Men are more commonly affected than women, although the average lifetime risk for both genders are similar (around 0.5-1%) .
It is recommended women of childbearing age should use contraceptives to avoid pregnancy and to discontinue its use if pregnancy is planned. [105] [124] Low dose of prednisolone, hydroxychloroquine and sulfasalazine are considered safe in pregnant women with rheumatoid arthritis. Prednisolone should be used with caution as the side effects ...
Cirrhosis is more common in men than in women. [158] The cost of cirrhosis in terms of human suffering, hospital costs, and lost productivity is high. Globally, age-standardized disability-adjusted life year (DALY) rates have decreased from 1990 to 2017, with the values going from 656.4 years per 100,000 people to 510.7 years per 100,000 people ...
The disease is more common in men than women, [2] [10] although the difference in rates has narrowed over recent decades, probably reflecting earlier increases in female smoking. In the United States, the risk for African Americans is over 50% greater than for whites , but the rates in Africa and East Asia are much lower than those in North ...
The prevalence of the disease continues to increase, most dramatically in low- and middle-income nations. [18] Rates are similar in women and men, with diabetes being the seventh leading cause of death globally. [19] [20] The global expenditure on diabetes-related healthcare is an estimated US$760 billion a year. [21]
An older term, febricula (a diminutive form of the Latin word for fever), was once used to refer to a low-grade fever lasting only a few days. This term fell out of use in the early 20th century, and the symptoms it referred to are now thought to have been caused mainly by various minor viral respiratory infections. [124]
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. [5] [6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. [7]