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For comparison, those with a V d L/kg body weight of less than 0.2 are mainly distributed in blood plasma, 0.2-0.7 mostly in the extracellular fluid and those with more than 0.7 are distributed throughout total body water.
The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [25] [26] [27] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet ...
The proper dosage of sulfadimethoxine depends on the animal species, the medical condition being treated, and the specific formulation of the medication. Using a tool like Sulfadimethoxine dosage calculator is important to determine the right dosage based on the animal's weight and species. [13] [14] [15]
Sulfamethoxazole inhibits dihydropteroate synthase, an enzyme involved further upstream in the same pathway. [24] Trimethoprim and sulfamethoxazole are commonly used in combination due to possible synergistic effects, and reduced development of resistance. [24] This benefit has been questioned. [26] Tetrahydrofolate synthesis pathway
Can be given to children less than 40 kilograms in weight; for children heavier, the dosage is same as adults, twice daily. ... Bactrim, Septra Sulfonamidochrysoidine ...
Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
Interim offensive coordinator Thomas Brown had a great plan involving a heavy dose of screens to keep the Vikings at bay and give Williams better opportunities when they did rip it downfield.
Drugs come with a recommended dose in milligrams or micrograms per kilogram of body weight, and that is used in conjunction with the patient's age and body weight to determine a safe dose. In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose.
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