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The incidence of the mutation is between 1 in 10,000 and 1 in 15,000 births. By age 35 years, 95% of individuals with FAP (>100 adenomas) have polyps. Without colectomy, colon cancer is virtually inevitable. The mean age of colon cancer in untreated individuals is 39 years (range 34–43 years). [13]
The oldest extant book on the genealogy of the Safavid family is Safvat as-safa and was written by Ibn Bazzaz in 1350, a disciple of Sheikh Sadr-al-Din Safavi, the son of Sheikh Safi ad-din Ardabili. According to Ibn Bazzaz, the Sheikh was a descendant of a Kurdish man named Firooz Shah Zarrin Kolah who was from Sanjar, southeast of Diyarbakir.
This list includes the biological mothers of Safavid shahs. There were eleven shahs (kings) of the Safavid Empire in ten generations. Throughout 235-years history the shahs were all members of the same house, the house of Safavid .
After the establishment of Safavid rule, official genealogies traced the lineage of Firuz Shah Zarrin-Kolah to the seventh of the Twelver Imams, Musa al-Kazim. In the Silsilat-an-Nasab-i Safaviya, composed during the reign of Suleiman I (1667–1694) and written by Shah Hussab ibn Abdal Zahidi, the ancestry of the Safavid is traced back to Ali. [4]
The Safavid Kings themselves claimed to be sayyids, [16] family descendants of the Islamic prophet Muhammad, although many scholars have cast doubt on this claim. [17] There seems now to be a consensus among scholars that the Safavid family hailed from Iranian Kurdistan, [5] and later moved to Iranian Azerbaijan, finally settling in the 11th century CE at Ardabil.
The male lineage of the Safavid family given by the oldest manuscript of the Safwat as-Safa is:"(Shaykh) Safi al-Din Abul-Fatah Ishaaq the son of Al-Shaykh Amin al-Din Jebrail the son of al-Saaleh Qutb al-Din Abu Bakr the son of Salaah al-Din Rashid the son of Muhammad al-Hafiz al-Kalaam Allah the son of Javaad the son of Pirooz al-Kurdi al ...
The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries. It is currently in its third revision (ICD-O-3). ICD-10 includes a list of ...
Familial adenomatous polyposis is a cancer syndrome in which there are hundreds to thousands of benign adenomas in the colon.. A hereditary cancer syndrome (familial/family cancer syndrome, inherited cancer syndrome, cancer predisposition syndrome, cancer syndrome, etc.) is a genetic disorder in which inherited genetic mutations in one or more genes predispose the affected individuals to the ...