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Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
Rituximab: an anti-CD20 monoclonal antibody, which has the ability to kill B cells, be they normal or malignant; Etoposide : a topoisomerase inhibitor from the group of epipodophyllotoxins; Prednisolone : a glucocorticoid hormone that can cause apoptosis and lysis of both normal and malignant lymphocytes ;
rituximab + bendamustine: follicular lymphoma and MALT lymphoma [7] R-DHAP or DHAP-R: rituximab + DHAP; that is, rituximab, dexamethasone (a steroid hormone), cytarabine (ara-C), platinum agent: relapsed non-Hodgkin's lymphoma and Hodgkin's lymphoma R-FCM or FCM-R: rituximab + FCM; that is, rituximab, fludarabine, cyclophosphamide, mitoxantrone
The translational work needed to implement these ideas is credited to Lee Nadler. As explained in an NIH article, "He was the first to discover monoclonal antibodies directed against human B-cell–specific antigens and, in fact, all the known human B-cell–specific antigens were discovered in his laboratory.
This regimen can also be combined with the monoclonal antibody rituximab if the lymphoma is of B cell origin; this combination is called R-CHOP. In 2002, a randomized controlled trial showed a higher complete response rate for R-CHOP vs CHOP in elderly patients with Diffuse Large-B-Cell Lymphoma (76% vs 63%). [ 4 ]
Scientists have long known that aging varies widely among individuals, influenced by genetics and lifestyle choices. Now, a new tool called CheekAge offers a simple, noninvasive way to predict ...
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