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A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]
DABA's main action is being an inhibitor of GABA transaminase, an enzyme that converts GABA back to glutamate. When the enzyme is inhibited, this conversion cannot happen, therefore, GABA levels are elevated. [1] It has also been observed that 2,4-diaminobutyric acid is a GABA reuptake inhibitor. [2] This action further elevates levels of GABA.
Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, [1] which acts as a potent and irreversible GABA transaminase inhibitor, [2] [3] and also a GABA reuptake inhibitor. [4] [5] Gabaculine is also known as 3-amino-2,3-dihydrobenzoic acid hydrochloride [6] and 5-amino cyclohexa-1,3 dienyl ...
Anandamide can be found within tissues in a wide range of animals. [1] [2] ... GABA, and glutamate. [14] ... which is an anandamide reuptake inhibitor. It may ...
Benzodiazepines work by increasing the effects of a neurotransmitter called gamma-amino butyric acid, or GABA. GABA is an inhibitory neurotransmitter — its job is to decrease activity in the ...
Pages in category "GABA reuptake inhibitors" The following 14 pages are in this category, out of 14 total. This list may not reflect recent changes. ...
SSRIs (selective serotonin reuptake inhibitors), which debuted in the 1980s, work on serotonin. SNRIs (serotonin and norepinephrine reuptake inhibitors) hit serotonin and norepinephrine.
It has demonstrated activity as a dopamine reuptake inhibitor, [5] and is also a negative allosteric modulator of the benzodiazepine site of the GABA A receptor. [5] [6] [7] Oroxylin A has been found to improve memory consolidation in mice by elevating brain-derived neurotrophic factor (BDNF) levels in the hippocampus. [8]