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Using the twenty natural amino acids, for example, in a tripeptide creates 8,000 (20 3) possibilities. Solid-phase methods for small molecules were later introduced and Furka devised a "split and mix" approach [2] [4] In its modern form, combinatorial chemistry has probably had its biggest impact in the pharmaceutical industry. [5]
This requires mixing the compounds in a reaction vessel, such as a chemical reactor or a simple round-bottom flask. Many reactions require some form of processing ("work-up") or purification procedure to isolate the final product. [1] The amount produced by chemical synthesis is known as the reaction yield.
Nuclear chemistry is a sub-discipline of chemistry that involves the chemical reactions of unstable and radioactive elements where both electronic and nuclear changes can occur. The substance (or substances) initially involved in a chemical reaction are called reactants or reagents .
These libraries can then be tested with enzymes or living organisms to find new active pharmaceutical substances. One drawback is the lack of chemical diversity of the products. Using the Ugi reaction in combination with other reactions enlarges the chemical diversity of possible products. Examples of Ugi reaction combinations:
In organic chemistry, an addition reaction is an organic reaction in which two or more molecules combine to form a larger molecule called the adduct. [1] [2] An addition reaction is limited to chemical compounds that have multiple bonds. Examples include a molecule with a carbon–carbon double bond (an alkene) or a triple bond (an alkyne).
In chemistry a one-pot synthesis is a strategy to improve the efficiency of a chemical reaction in which a reactant is subjected to successive chemical reactions in just one reactor. This is much desired by chemists because avoiding a lengthy separation process and purification of the intermediate chemical compounds can save time and resources ...
In one important reaction type, a main group organometallic compound of the type R-M (where R = organic group, M = main group centre metal atom) reacts with an organic halide of the type R'-X with formation of a new carbon-carbon bond in the product R-R'. The most common type of coupling reaction is the cross coupling reaction. [1] [2] [3]
In organic chemistry, a cross-coupling reaction is a reaction where two different fragments are joined. Cross-couplings are a subset of the more general coupling reactions. Often cross-coupling reactions require metal catalysts. One important reaction type is this: