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Timing is everything for many things in life — including when to take medication like metformin, sold under the brand names Glucophage, Fortamet, Riomet, and Glumetza.
Gastrointestinal upset can cause severe discomfort; it is most common when metformin is first administered, or when the dose is increased. [ 76 ] [ 81 ] The discomfort can often be avoided by beginning at a low dose (1.0 to 1.7 g/day) and increasing the dose gradually, but even with low doses, 5% of people may be unable to tolerate metformin.
Diarrhea. Flatulence. Asthenia (feeling weak or lacking energy) Stomach pain. Headache. Metformin can also cause a vitamin B12 deficiency, which may be linked with anemia. Stopping the medication ...
Diarrhea is a well-known side effect of metformin. Learn more about why this gut-related side effect happens and how to manage it. Diarrhea is a well-known side effect of metformin. Learn more ...
Since alpha-glucosidase inhibitors prevent the degradation of complex carbohydrates into glucose, the carbohydrates will remain in the intestine. In the colon, bacteria will digest the complex carbohydrates, thereby causing gastrointestinal side effects such as flatulence and diarrhea. Since these effects are dose-related, it is generally ...
Apparently, the (unknown) mechanism of induction of diarrhea caused by metformin is different than for ordinary diarrhea. A distinguishing feature of metformin-induced diarrhea is that it is associated with strong, painful intestinal cramping that occurs irrespective of what is in the colon. The initial bowel motions may be quite solid.