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Primary amines can be protected as benzophenone imines, and the protected amines are stable in flash chromatography. [7] Buchwald-Hartwig amination involves coupling aromatic halide and amine to form carbon-nitrogen bonds with the help of palladium-based catalysts. Benzophenone imine can be used as an ammonia-equivalent in such reactions. [1]
Benzophenone is a naturally occurring organic compound with the formula (C 6 H 5) 2 CO, generally abbreviated Ph 2 CO. Benzophenone has been found in some fungi, fruits and plants, including grapes. [4] It is a white solid with a low melting point and rose-like odor [5] that is soluble in organic solvents. Benzophenone is the simplest ...
Many ketones contain the benzoyl group. They have the formula C 6 H 5 CO–R, an important example being benzophenone. Benzoyl esters and amides are common in organic chemistry. The esters are used as a protecting groups in organic synthesis, [4] which can be easily removed by hydrolysis in dilute basic solution.
In organic chemistry, an oxime is an organic compound belonging to the imines, with the general formula RR’C=N−OH, where R is an organic side-chain and R' may be hydrogen, forming an aldoxime, or another organic group, forming a ketoxime.
The o-hydroxyphenacyl PPG has been introduced as an alternative with absorption band shifted closer towards the visible region, however it has slightly lower quantum yields of deprotection (generally 0.1-0.3) due to excited state proton transfer available as an alternative deactivation pathway.
Orthogonal protection is a strategy allowing the specific deprotection of one protective group in a multiply-protected structure. For example, the amino acid tyrosine could be protected as a benzyl ester on the carboxyl group, a fluorenylmethylenoxy carbamate on the amine group, and a tert -butyl ether on the phenol group.
When R = H, the compound is a primary imine, when R is hydrocarbyl, the compound is a secondary imine. If this group is not a hydrogen atom, then the compound can sometimes be referred to as a Schiff base. [9] When R 3 is OH, the imine is called an oxime, and when R 3 is NH 2 the imine is called a hydrazone.
Benzophenone imine, an organic compound with the formula of (C 6 H 5) 2 C=NH; 2-Aminofluorene, a synthetic arylamine This page was last edited on 28 February 2023, at ...