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Thus patients may not initially notice small wounds to legs and feet, and may therefore fail to prevent infection or repeated injury. [8] Further, diabetes causes immune compromise and damage to small blood vessels, preventing adequate oxygenation of tissue, which can cause chronic wounds. [8]
Diabetic nephropathy, damage to the kidney due to increased glomerular pressure and hyperfiltration can lead to end-stage chronic kidney disease that may require renal dialysis. [27] In most parts of the world, diabetes mellitus is the leading cause of end-stage kidney disease (ESKD).
Diabetic nephropathy, also known as diabetic kidney disease, [5] is the chronic loss of kidney function occurring in those with diabetes mellitus. Diabetic nephropathy is the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally. The triad of protein leaking into the urine (proteinuria or albuminuria ...
Nonfreezing cold injury commonly affects the feet due to prolonged exposure to wet socks or cold standing water. [4] Symptoms progress through a series of four stages. [4] [15] A severe case of trench foot. During cold exposure. Affected skin becomes numb, which can cause a clumsy walking pattern if the feet are affected
The risk of infection is increased with traumatic injury to the skin and also in people with certain underlying conditions such as diabetes, chronic venous insufficiency and immunosuppression. [3] Staphylococcal and Streptococcal organisms remain the most common causes of superficial infection after a flooding event. [4]
The pathological mechanism by which frostbite causes body tissue injury can be characterized by four stages: Prefreeze, freeze-thaw, vascular stasis, and the late ischemic stage. [16] Prefreeze phase: involves the cooling of tissues without ice crystal formation. [16] Freeze-thaw phase: ice-crystals form, resulting in cellular damage and death ...
Non-freezing cold injuries (NFCI) is a class of tissue damage caused by sustained exposure to low temperature without actual freezing. [1] There are several forms of NFCI, and the common names may refer to the circumstances in which they commonly occur or were first described, such as trench foot, which was named after its association with trench warfare.
Necrobiosis lipoidica is a rare, chronic skin condition predominantly associated with diabetes mellitus (known as necrobiosis lipoidica diabeticorum or NLD). [1] It can also occur in individuals with rheumatoid arthritis or without any underlying conditions ( idiopathic ). [ 2 ]