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Ephedrine promotes modest short-term weight loss, [24] specifically fat loss, but its long-term effects are unknown. [25] In mice, ephedrine is known to stimulate thermogenesis in the brown adipose tissue , but because adult humans have only small amounts of brown fat, thermogenesis is assumed to take place mostly in the skeletal muscle .
Only a single placebo-controlled study of pseudoephedrine for weight loss exists (120 mg/day slow-release for 12 weeks) and found no significant difference in weight lost compared to placebo (-4.6 kg vs. -4.5 kg).
The Ephedra alkaloids, ephedrine and pseudoephedrine – constituents of E. sinica and other members of the genus – have sympathomimetic and decongestant qualities, [22] and have been used as dietary supplements, mainly for weight loss. [23] The drug ephedrine is used to prevent low blood pressure during spinal anesthesia. [22]
A wide variety of alkaloid and non-alkaloid compounds have been identified in various species of Ephedra.Of the six ephedrine-type ingredients found in ephedra (at concentrations of 0.02-3.4%), the most common are ephedrine and pseudoephedrine, [13] which are the sources of its stimulant and thermogenic effects. [4]
[17] [18] [19] Chemically, phenylpropanolamine is a substituted amphetamine and is closely related to ephedrine, pseudoephedrine, amphetamine, and cathinone. [ 20 ] [ 21 ] [ 22 ] [ 11 ] It is usually a racemic mixture of the (1 R ,2 S )- and (1 S ,2 R )- enantiomers of β-hydroxyamphetamine and is also known as dl -norephedrine.
Bansal compares weight-loss results from Zepbound to that of bariatric surgery, which can lead to weight loss of 10% to 15% of a patient's body weight, and surgical procedures like gastric sleeve ...