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Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. [4] The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). [ 4 ]
PDE4 also regulates the D 1 /PKA/DARPP-32 signalling cascade in the frontal cortex, which may contribute to the antipsychotic and procognitive effects of PDE4 inhibitors. [16] Whereas PDE4C is expressed primarily in the periphery and hence may be partly responsible for the peripheral effects of PDE4 inhibitors (e.g. their anti-inflammatory ...
Everolimus was used in a clinical trial by Novartis, and short-term treatment was shown to enhance the response to the influenza vaccine in the elderly, possible by reversing immunosenescence. [38] Everolimus treatment of mice results in reduced metabolic side effects compared to sirolimus. [30]
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Prepare for potential side effects. Taking metformin may cause unpleasant side effects like diarrhea, nausea, upset stomach and, in rare cases, lactic acidosis.
As interest in taking glucagon-like peptide-1 receptor agonist (GLP-1 agonist) medications, such as Zepbound and Wegovy, for weight loss, research continues to examine potential new side effects ...
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