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Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. [4] The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). [ 4 ]
PDE4 also regulates the D 1 /PKA/DARPP-32 signalling cascade in the frontal cortex, which may contribute to the antipsychotic and procognitive effects of PDE4 inhibitors. [16] Whereas PDE4C is expressed primarily in the periphery and hence may be partly responsible for the peripheral effects of PDE4 inhibitors (e.g. their anti-inflammatory ...
Ibudilast has bronchodilator, vasodilator [10] and neuroprotective effects, [11] [12] and is mainly used in the treatment of asthma and stroke. [13] It inhibits platelet aggregation, [14] and may also be useful in the treatment of multiple sclerosis. [15] Ibudilast crosses the blood–brain barrier and suppresses glial cell activation.
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
Celgene has good news -- and it has bad news. The company announced phase 3 results for apremilast in treating psoriasis at the American Academy of Dermatology meeting this weekend in Miami.
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