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It is easiest to describe the flux of metabolites through a pathway by considering the reaction steps individually. The flux of the metabolites through each reaction (J) is the rate of the forward reaction (V f), less that of the reverse reaction (V r): [2]
The significance of fluxomics is that metabolic fluxes determine the cellular phenotype. [3] It has the added advantage of being based on the metabolome which has fewer components than the genome or proteome. [4] Fluxomics falls within the field of systems biology which developed with the appearance of high throughput technologies. [5]
Physiology (/ ˌ f ɪ z i ˈ ɒ l ə dʒ i /; from Ancient Greek φύσις (phúsis) 'nature, origin' and -λογία () 'study of') [1] is the scientific study of functions and mechanisms in a living system.
Fick's first law relates the diffusive flux to the gradient of the concentration. It postulates that the flux goes from regions of high concentration to regions of low concentration, with a magnitude that is proportional to the concentration gradient (spatial derivative), or in simplistic terms the concept that a solute will move from a region of high concentration to a region of low ...
Metabolic flux analysis (MFA) is an experimental fluxomics technique used to examine production and consumption rates of metabolites in a biological system. At an intracellular level, it allows for the quantification of metabolic fluxes, thereby elucidating the central metabolism of the cell. [1]
Oceanic freshwater fluxes are defined as the transport of non saline water between the oceans and the other components of the Earth's system (the lands, the atmosphere and the cryosphere). These fluxes have an impact on the local ocean properties (on sea surface salinity , temperature and elevation ), as well as on the large scale circulation ...
Claude Bernard, French physician who introduced the concept of homeostasis. The human body and even its individual body fluids may be conceptually divided into various fluid compartments, which, although not literally anatomic compartments, do represent a real division in terms of how portions of the body's water, solutes, and suspended elements are segregated.
On the organ and tissue scale in mammals and other animals, examples include the circulatory system, the respiratory system, and the nervous system. On the micro to the nanoscopic scale, examples of biological systems are cells, organelles, macromolecular complexes and regulatory pathways.