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Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer , oesophageal cancer , stomach cancer , pancreatic cancer , breast cancer , and cervical cancer . [ 3 ]
Fluorodeoxyuridylate, [1] also known as FdUMP, 5-fluoro-2'-deoxyuridylate, and 5-fluoro-2'-deoxyuridine 5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops the rapidly proliferation ...
Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU. [1] It was patented in 1967 and approved for medical use in 1972. [2]
1.0 km (0.62 mi) km mi; metre: m m US spelling: meter: 1.0 m (3 ft 3 in) m ft; m ftin; centimetre: cm cm US spelling: centimeter: 1.0 cm (0.39 in) cm in; millimetre: mm mm US spelling: millimeter: 1.0 mm (0.039 in) mm in; micrometre: μm (um) μm US spelling: micrometer: 1.0 μm (3.9 × 10 −5 in) nanometre: nm nm US spelling: nanometer: 1.0 ...
1,1-disub. alkenes 1655 medium cis-1,2-disub. alkenes 1660 medium trans-1,2-disub. alkenes 1675 medium trisub., tetrasub. alkenes 1670 weak conjugated C═C dienes 1600 strong 1650 strong with benzene ring 1625 strong with C═O 1600 strong C═C (both sp 2) any 1640–1680 medium aromatic C═C any 1450 weak to strong (usually 3 or 4) 1500 1580
Floxuridine is rapidly catabolized to 5-fluorouracil, which is the active form of the drug. The primary effect is interference with DNA synthesis and to a lesser extent, inhibition of RNA formation through the drug's incorporation into RNA , thus leading to the production of fraudulent RNA.
Cyclophosphamide Methotrexate Fluorouracil (CMF) is a commonly used regimen of breast cancer chemotherapy that combines three anti-cancer agents: cyclophosphamide, ...
As fluorouracil, carmofur has been known to induce leukoencephalopathy, characterized by progressive damage to white matter in the brain with stroke-like symptoms. [ 8 ] [ 9 ] [ 10 ] A clinical trial for small hepatocellular carcinoma was stopped prematurely because 56% of the treated patients had unacceptable side effects.