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Metronidazole, sold under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. [11] It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. [11] It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis. [11]
TOL-463 is an anti-infective medication which is under development for the treatment of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) (vaginal yeast infection). [ 3 ] [ 1 ] [ 4 ] [ 2 ] It is a boric acid -based vaginal anti-infective enhanced with ethylenediaminetetraacetic acid (EDTA) which was designed to have improved activity ...
[5] [19] [21] [10] [22] [23] It is specifically used following treatment with or in combination with nitroimidazoles like metronidazole for recurrent bacterial vaginosis. [ 5 ] [ 22 ] [ 10 ] Although it has been reported to be effective and is widely used for this purpose, clinical studies of boric acid for treatment of bacterial vaginosis are ...
Bacterial vaginosis — an overgrowth of bacteria that can cause discharge and a "fishy" odor — is the most common vaginal infection in women, affecting nearly 30% between 15 and 44 years old, ...
Bacterial vaginosis: The most commonly used antibiotics are metronidazole, available in both pill and gel form, and clindamycin available in both pill and cream form. [11] Yeast infections: Local azole, in the form of ovula and cream. All agents appear to be equally effective. [33]
Medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group of hormones including progesterone), and antibacterials and antifungals to treat bacterial vaginosis and yeast infections respectively.