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Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, ... Chronic pain and neuropathic pain are indications for which there is high unmet need in the clinic.
Tapentadol is used for the treatment of moderate to severe pain for both acute (following e.g. injury or surgery) and chronic musculoskeletal pain. [29] It is also specifically indicated for controlling the pain of diabetic neuropathy when around-the-clock opioid medication is required.
Palmitoylethanolamide has been evaluated for its analgesic actions in a great variety of pain indications [70] and found to be safe and effective. Modulation of the endocannabinoid system by metabolism to N-arachidinoyl-phenolamine (AM404), an endogenous cannabinoid neurotransmitter, has been discovered to be one mechanism [ 71 ] for analgesia ...
This is the first class of non-opioid pain medication approved to treat moderate to severe acute pain approved by the FDA in more than 20 years. The U.S. Food and Drug Administration (FDA) on ...
Acute pain — sudden or urgent pain that results from injury, trauma or surgery — affects more than 80 million Americans annually and is the most common reason for emergency department visits ...
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone. [4] [5] OIH is not necessarily confined to the original affected site. [6]