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Perrottetinene, a moderately psychoactive cannabinoid, [46] has been isolated from different Radula varieties. Machaeriol A and related compounds are found in plants from the Machaerium family. [47] Most of the phytocannabinoids are nearly insoluble in water but are soluble in lipids, alcohols, and other non-polar organic solvents.
Various strains of "medical cannabis" are found to have a significant variation in the ratios of CBD-to-THC and are known to contain other non-psychotropic cannabinoids. [44] Any psychoactive cannabis, regardless of its CBD content, is derived from the flower (or bud) of the genus Cannabis.
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [ 1 ] [ 2 ] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis .
Heat is required to decarboxylate the non-psychoactive phytocannabinoid THCA to its psychoactive form, THC. Likewise, CBDA turns into CBD. From hemp plant material in an oven, cannabinoid concentration plots (time/temp) show THC: [16] STP 0 minutes 0.20mg/g; 140-160C 20 minutes 0.27mg/g; 140-160C 60 minutes 0.05-0.15mg/g; 120C 45 minutes 0.27mg/g
Cannabigerol (CBG) is a non-psychoactive cannabinoid and minor constituent of cannabis. [1] [2] [3] [4] It is one of more than 120 identified cannabinoids found in ...
Tetrahydrocannabivarin (THCV, THV, O-4394, GWP42004) is a homologue of tetrahydrocannabinol (THC) having a propyl (3-carbon) side chain instead of pentyl (5-carbon), making it non-psychoactive in lower doses.
The two cannabinoids usually produced in greatest abundance are cannabidiol (CBD) and/or Δ 9-tetrahydrocannabinol (THC), but only THC is psychoactive. [55] Since the early 1970s, Cannabis plants have been categorized by their chemical phenotype or "chemotype", based on the overall amount of THC produced, and on the ratio of THC to CBD. [ 56 ]
Cannabicyclol (CBL) is a non-psychoactive cannabinoid found in Cannabis. CBL is a degradative product like cannabinol, with cannabichromene degrading into CBL through natural irradiation [1] or under acid conditions. [2] CBL is not scheduled under the Convention on Psychotropic Substances.