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The clinical uses of MEG are in detecting and localizing pathological activity in patients with epilepsy, and in localizing eloquent cortex for surgical planning in patients with brain tumors or intractable epilepsy. The goal of epilepsy surgery is to remove the epileptogenic tissue while sparing healthy brain areas. [29]
The initial motivation for EEG-fMRI was in the field of research into epilepsy, and in particular the study of interictal epileptiform discharges (IED, or interictal spikes), and their generators, and of seizures. IED are unpredictable and sub-clinical events in patients with epilepsy that can only be observed using EEG (or MEG).
Some patients may have disorders such as compulsive lying, which makes certain studies impossible. [49] It is harder for those with clinical problems to stay still for long. Using head restraints or bite bars may injure epileptics who have a seizure inside the scanner; bite bars may also discomfort those with dental prostheses. [50]
CT scans can expose patients to levels of radiation 100-500 times higher than traditional x-rays, with higher radiation doses producing better resolution imaging. [37] While easy to use, increases in CT scan use, especially in asymptomatic patients, is a topic of concern since patients are exposed to significantly high levels of radiation. [36]
For patients with intractable epilepsy – epilepsy that is unresponsive to anticonvulsants – surgical treatment may be a viable treatment option. Partial epilepsy [ 14 ] is the common intractable epilepsy and the partial seizure is difficult to locate.Treatment for such epilepsy is limited to attachment of vagus nerve stimulator.
MRI, fMRI, MEG data for ~700 population-derived healthy adults aged 18–88 Human Macroscopic Images, Descriptive, Numerical Healthy No [18] The Cancer Imaging Archive MRI, CT, and PET imaging of cancer patients with supporting clinical data (in many cases) Human Macroscopic Images, Descriptive, Numerical Cancer No [19]