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The cross-linking theory proposes that advanced glycation end-products (stable bonds formed by the binding of glucose to proteins) and other aberrant cross-links accumulating in aging tissues is the cause of aging. The crosslinking of proteins disables their biological functions.
DNA cross-linking can in turn lead to various effects of aging, especially cancer. [21] Other cross-linking can occur between fat and protein molecules, which leads to wrinkles. [22] Free radicals can oxidize LDL, and this is a key event in the formation of plaque in arteries, leading to heart disease and stroke. [23]
Permanent link; Page information; ... Aging theories based on group selection; Antagonistic pleiotropy hypothesis; C. Cross-linking theory of aging; D.
The network theory of aging provides a deeper look at the damage and repair processes at the cellular level and the ever changing balance between those processes. To fully understand the network theory as its applied to aging you must look at the different hierarchical elements of the theory as it pertains to aging.
Cross-links. Crosslinking of DNA; Free radicals – atom, molecule, or ion that has unpaired valence electrons. With some exceptions, these unpaired electrons make free radicals highly chemically reactive towards other substances, or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other.
Aging theories based on evolvability; Aging theories based on group selection; Antagonistic pleiotropy hypothesis; C. Cross-linking theory of aging; D. Disposable ...
Aging brain; Calorie restriction; Cross-link; Crosslinking of DNA; Degenerative disease; DNA damage theory of aging; Exposure to ultraviolet light; Free-radical damage; Glycation; Life expectancy; Longevity; Maximum life span; Senescence; Stem cell theory of aging
A ACE inhibitor Actuarial escape velocity Adenosine triphosphate (ATP) Advanced Cell Technology Corporation Aerobic exercise Age-adjusted life expectancy Age-Related Eye Disease Study Age-Related Macular Degeneration Aging Aging and memory Aging-associated diseases Aging brain Aging population Alcor Life Extension Foundation Alternative medicine American Aging Association American Academy of ...