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Corneal cross-linking (CXL) with riboflavin (vitamin B 2) and UV-A light is a surgical treatment for corneal ectasia such as keratoconus, [2] PMD, and post-LASIK ectasia. It is used in an attempt to make the cornea stronger. According to a 2015 Cochrane review, there is insufficient evidence to determine if it is useful in keratoconus. [3]
In 2016, however, the FDA approved cross-linking surgery as a treatment for keratoconus and recommended that a registry system should be set-up to evaluate the long-term treatment effect. [ 10 ] [ 71 ] The Save Sight Keratoconus Registry is an international database of keratoconus patients that is tracking outcomes of cross-linking in patients ...
Keratoconus, a progressive thinning of the cornea, is a common corneal disorder. Keratoconus occurring after refractive surgery is called Corneal Ectasia. It is believed that additional thinning of the cornea via refractive surgery may contribute to advancement of the disease [31] that may lead to the need for a corneal transplant.
LASIK or Lasik (/ ˈ l eɪ s ɪ k /; "laser-assisted in situ keratomileusis"), commonly referred to as laser eye surgery or laser vision correction, is a type of refractive surgery for the correction of myopia, hyperopia, and astigmatism. [1]
Before corneal refractive surgery such as LASIK, SMILE, and PRK, people must be examined for possible risk factors such as keratoconus. [3]Abnormal corneal topography compromises of keratoconus, pellucid marginal degeneration, or forme fruste keratoconus with an I-S value of 1.4 or more [4] is the most significant risk factor.
There is evidence suggesting corneal collagen cross-linking may be beneficial for patients with pellucid marginal degeneration. [12] [13] [14] Research shows some promising results by combining collagen cross linking with photorefractive keratectomy, or with topography-guided transepithelial surface ablation. [7]
Healing time from ALK is very rapid, usually in about 24 hours or so. Results are immediately realized, though it may take several months for the vision correction to finally stabilize. On the down side, the results of ALK are not as highly predictable as with the laser procedures of LASIK or PRK . [ 1 ]
Corneal hydrops is an uncommon complication seen in people with advanced keratoconus or other corneal ectatic disorders, [1] and is characterized by stromal edema due to leakage of aqueous humor through a tear in Descemet's membrane. [2]