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Darier's disease (DD) is a rare, genetic skin disorder. It is an autosomal dominant disorder, that is, if one parent has DD, there is a 50% chance than a child will inherit DD. It was first reported by French dermatologist Ferdinand-Jean Darier in 1889.
White is one of the namesakes of Darier–White disease, having discovered it independently of Ferdinand-Jean Darier. [1] [2] He also wrote a book, Dermatitis Venenata, published in 1887. [3] White's Back Bay residence, designed by Peabody & Stearns
Polydactylous longitudinal erythronychia has been most commonly associated with Darier's disease [10] and lichen planus [11] but has also occasionally been associated with acantholytic epidermolysis bullosa, [12] no association, [13] graft-versus-host disease, [14] [15] hemiplegia, [16] and systemic amyloidosis. [11]
Darier's sign is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria pigmentosa. [1] In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain ...
The other diseases were a follicular keratosis (Darier-White syndrome), dermatofibrosarcoma (Darier-Ferrand disease), erythema annularis, subcutaneous sarcoidosis (Darier-Roussy sarcoid), and a sign, Darier's sign observed in mastocytosis. From 1909 to 1922, Darier was head of the clinical department at the Hôpital Saint-Louis. [5]
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It was first described by Darier in 1916. [ 3 ] [ 4 ] [ 5 ] Many different terms have been used to classify these types of lesions and it is still controversial on what exactly defines EAC. Some of the types include annular erythema (deep and superficial), erythema perstans, erythema gyratum perstans, erythema gyratum repens, darier erythema ...
“The history of 12-step came out of white, middle-class, Protestant people who want to be respectable,” said historian Nancy Campbell, a professor at Rensselaer Polytechnic Institute. “It offers a form of community and a form of belonging that is predicated upon you wanting to be normal, you wanting to be respectable, you wanting to have ...