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Decidualization is a process that results in significant changes to cells of the endometrium in preparation for, and during, pregnancy. This includes morphological and functional changes (the decidual reaction ) to endometrial stromal cells (ESCs), the presence of decidual white blood cells (leukocytes), and vascular changes to maternal arteries.
The decidua is the modified mucosal lining of the uterus (that is, modified endometrium) that forms every month, in preparation for pregnancy. It is shed off each month when there is no fertilized egg to support. [1] The decidua is under the influence of progesterone. Endometrial cells become highly characteristic.
Experimentally, human endometrial stromal cells can be decidualized in culture by using analogs of cAMP and progesterone. The cells will exhibit a decidualized phenotype and display upregulation of common decidualization markers such as prolactin and IGFBP1. [3]
The uterine glands, on the other hand, decrease in activity and degenerate around 8 to 9 days [30] after ovulation in absence of pregnancy. The decidual cells originate from the stromal cells that are always present in the endometrium, and make up a new layer, the decidua .
Ectopic decidua are decidual cells found outside inner lining of the uterus. This condition was first described in 1971 by Walker [1] and the name 'ectopic decidua' was coined by Tausig. [2] While ectopic decidua is most commonly seen during pregnancy, it rarely occurs in non-pregnant people, accompanied by bleeding and pain. [citation needed]
Menstrual cycle The menstrual cycle is a series of natural changes in hormone production and the structures of the uterus and ovaries of the female reproductive system that makes pregnancy possible. The ovarian cycle controls the production and release of eggs and the cyclic release of estrogen and progesterone. The uterine cycle governs the preparation and maintenance of the lining of the ...
Women's endometrium contains relaxin, which is an essential component that helps prepare the body for early pregnancy. [21] The endometrium is transformed into decidua during the early pregnancy maintenance procedure. [21] The process known as decidualization occurs when the endometrium changes both physiologically and morphologically in order ...
Nevertheless, in human a perfect synchrony is not necessary; if the endometrium is not ready to receive the embryo an ectopic pregnancy may occur. This consist of the implantation of the blast outside the uterus, which can be extremely dangerous.