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The extracellular fluid, in particular the interstitial fluid, constitutes the body's internal environment that bathes all of the cells in the body. The ECF composition is therefore crucial for their normal functions, and is maintained by a number of homeostatic mechanisms involving negative feedback .
The main intravascular fluid in mammals is blood, a complex mixture with elements of a suspension (blood cells), colloid (), and solutes (glucose and ions).The blood represents both the intracellular compartment (the fluid inside the blood cells) and the extracellular compartment (the blood plasma).
[1] [2] The fluid in this space is called interstitial fluid, comprises water and solutes, and drains into the lymph system. [2] The interstitial compartment is composed of connective and supporting tissues within the body – called the extracellular matrix – that are situated outside the blood and lymphatic vessels and the parenchyma of organs.
Perilymph is the fluid contained within the bony labyrinth, surrounding and protecting the membranous labyrinth; perilymph resembles extracellular fluid in composition (sodium salts are the predominant positive electrolyte) and, via the cochlear aqueduct (sometimes referred to as the "perilymphatic duct"), is in continuity with cerebrospinal fluid.
The total body of water is divided into fluid compartments, [1] between the intracellular fluid compartment (also called space, or volume) and the extracellular fluid (ECF) compartment (space, volume) in a two-to-one ratio: 28 (28–32) liters are inside cells and 14 (14–15) liters are outside cells.
Extracellular fluid (1/3 of body water) is fluid contained in areas outside of cells. For a 40-litre body, about 15 litres is extracellular, [9] which amounts to 37.5%. Plasma (1/5 of extracellular fluid). Of this 15 litres of extracellular fluid, plasma volume averages 3 litres, [9] or 20%. Interstitial fluid (4/5 of extracellular fluid)
Ground substance is an amorphous gel-like substance in the extracellular space of animals that contains all components of the extracellular matrix (ECM) except for fibrous materials such as collagen and elastin. [1] Ground substance is active in the development, movement, and proliferation of tissues, as well as their metabolism.
Cerebrospinal fluid (CSF) is a clear, colorless transcellular body fluid found within the meningeal tissue that surrounds the vertebrate brain and spinal cord, and in the ventricles of the brain. CSF is mostly produced by specialized ependymal cells in the choroid plexuses of the ventricles of the brain, and absorbed in the arachnoid ...