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Dopaminergic pathways (dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including movement, cognition, executive functions, reward, motivation, and neuroendocrine control. [1] Each pathway is a set of projection neurons, consisting of individual dopaminergic neurons.
Dopamine receptor D 2, also known as D 2 R, is a protein that, in humans, is encoded by the DRD2 gene.After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D 2 receptor. [5]
The D 2-like receptors [1] are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. The D 2-like subfamily consists of three G-protein coupled receptors that are coupled to G i /G o and mediate inhibitory neurotransmission, of which include D 2, D 3, and D 4. For more information, please see the respective main ...
The mesocortical pathway is a dopaminergic pathway that connects the ventral tegmentum to the prefrontal cortex. It is one of the four major dopamine pathways in the brain . It is essential to the normal cognitive function of the dorsolateral prefrontal cortex (part of the frontal lobe), and is thought to be involved in cognitive control ...
Tuberoinfundibular pathway shown in opaque blue, connecting that hypothalamus with the pituitary gland. The tuberoinfundibular pathway refers to a population of dopamine neurons that project from the arcuate nucleus (a.k.a. the "infundibular nucleus") in the tuberal region of the hypothalamus to the median eminence. [1]
Medium spiny neurons have two primary phenotypes (characteristic types): D1-type MSNs of the direct pathway and D2-type MSNs of the indirect pathway. [ 2 ] [ 3 ] [ 4 ] Most striatal MSNs contain only D1-type or D2-type dopamine receptors , but a subpopulation of MSNs exhibit both phenotypes.
The mesolimbic pathway and its positioning in relation to the other dopaminergic pathways. The mesolimbic pathway is a collection of dopaminergic (i.e., dopamine-releasing) neurons that project from the ventral tegmental area (VTA) to the ventral striatum, which includes the nucleus accumbens (NAcc) and olfactory tubercle. [9]
Dopamine receptor flow chart. Dopamine receptors are all G protein–coupled receptors, and are divided into two classes based on which G-protein they are coupled to. [1] The D 1-like class of dopamine receptors is coupled to Gα s/olf and stimulates adenylate cyclase production, whereas the D 2-like class is coupled to Gα i/o and thus inhibits adenylate cyclase production.