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Mepolizumab. Mepolizumab, sold under the brand name Nucala by GlaxoSmithKline, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis, and hypereosinophilic syndrome (HES). [5] It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system.
Dexpramipexole is a first-in-class oral investigational medicine that lowers blood and tissue eosinophils before they can cause damage in the target organ. Dexpramipexole is being developed by Areteia Therapeutics and has the potential to be the first oral treatment ever approved for eosinophilic asthma.
It is approved for people who have a history of severe asthma attacks (exacerbations) despite receiving their current asthma medicines. [7] In June 2016, the European Medicines Agency recommended the granting of a marketing authorisation for reslizumab (Cinqaero) intended as add-on treatment in adults with severe eosinophilic asthma. [6]
Asthma is a long-term inflammatory disease of the airways of the lungs. [ 4 ] It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. [ 9 ][ 10 ] Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. [ 3 ]
Treatment. corticosteroids. Eosinophilic bronchitis (EB) is a type of airway inflammation due to excessive mast cell recruitment and activation in the superficial airways as opposed to the smooth muscles of the airways as seen in asthma. [1][2] It often results in a chronic cough. [1] Lung function tests are usually normal. [1]
Respirology. Eosinophilic pneumonia is a disease in which an eosinophil, a type of white blood cell, accumulates in the lungs. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. Several different kinds of eosinophilic pneumonia exist and can occur in any age group.
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