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Coagulation factor VIII (Factor VIII, FVIII, also known as anti-hemophilic factor (AHF)) is an essential blood clotting protein. In humans, it is encoded by F8 gene. [5] [6] Defects in this gene result in hemophilia A, an X-linked bleeding disorder. [7]
Blood clotting factor VIII (FVIII) is the nonenzymatic cofactor to the activated clotting factor IX (FIXa), which, when proteolytically activated, interacts with FIXa to form a tight noncovalent complex that binds to and activates factor X (FX).
This test measures the activity of factor VIII, a blood-clotting protein. The test can find out whether you have hemophilia A or another clotting disorder. Hemophilia A is the most common severe bleeding disorder. In hemophilia A, blood doesn't clot as it should.
Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn't clot properly. People with the disease have low levels of von Willebrand factor, a protein that helps blood clot, or the protein doesn't perform as it should.
Factor VIII circulates in an inactive form bound to von Willebrand factor (VWF) until blood vessel injury activates it and separates them. Free Factor VIII then interacts with factor IX to facilitate clotting.
Hemophilia is a rare disorder in which the blood doesn't clot in the typical way because it doesn't have enough blood-clotting proteins (clotting factors). If you have hemophilia, you might bleed for a longer time after an injury than you would if your blood clotted properly.
The purified proteins retain one or more of the known properties of factor VIII, including the acceleration of factor IXa-mediated activation of factor X, ability to be activated by thrombin and factor Xa, inactivation by activated protein C, and by human antibodies to factor VIII.
Higher factor VIII (FVIII) levels are a known cardiovascular disease risk factor. We here examine the epidemiological and genetic correlates of FVIII in African Americans. FVIII was associated with incident heart failure, mortality, and coronary heart disease.
Hepatocytes are responsible for providing the body with clotting factors XIII, XII, XI, X, IX, VII, V, II, and I. Clotting factors VIII (antihemophilic factor A) and III (tissue factor) originate from endothelial cells, whereas clotting factor IV (calcium ion) is freely available in plasma.
There are a variety of tests to measure how well the von Willebrand factor works in your clotting process. Factor VIII clotting activity. This shows whether you have abnormally low levels and activity of factor VIII.