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Lorazepam's effects are dose-dependent, meaning the higher the dose, the stronger the effects (and side effects) will be. Using the smallest dose needed to achieve desired effects lessens the risk of adverse effects. Sedative drugs and sleeping pills, including lorazepam, have been associated with an increased risk of death. [58]
Symptoms. Effects of long-term benzodiazepine use may include disinhibition, impaired concentration and memory, depression, [ 19 ][ 20 ] as well as sexual dysfunction. [ 6 ][ 21 ] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [ 22 ]
The rate of dosage reduction is best carried out so as to minimize the symptoms' intensity and severity. Anecdotally, a slow rate of reduction may reduce the risk of developing a severe protracted syndrome. Long half-life benzodiazepines like diazepam [1] or chlordiazepoxide are preferred to minimize rebound effects and are available in low ...
The changes are most notable with long acting benzodiazepines as these are prone to significant accumulation in such individuals and can lead to withdrawal symptoms. [citation needed] For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual.
Low- or normal-dose dependence was not suspected until the 1970s, and it was not until the early 1980s that it was confirmed. [69] [70] Low-dose dependence has now been clearly demonstrated in both animal studies and human studies, [71] [72] and is a recognized clinical disadvantage of benzodiazepines. Severe withdrawal syndromes can occur from ...
v. t. e. Benzodiazepine use disorder (BUD), also called misuse or abuse, [1] is the use of benzodiazepines without a prescription and/or for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. [2][3] Benzodiazepines are one of the more common prescription drugs used recreationally.
t. e. Benzodiazepine overdose (BZD OD) describes the ingestion of one of the drugs in the benzodiazepine class in quantities greater than are recommended or generally practiced. The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech.
Lorazepam has particularly marked amnesic properties that may make it more effective when amnesia is the desired effect. [ 24 ] : 693 Benzodiazepines are well known for their strong muscle-relaxing properties and can be useful in the treatment of muscle spasms, [ 24 ] : 577–578 although tolerance often develops to their muscle relaxant ...
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