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Although research in vitro indicates polyphenols are good antioxidants and probably influence the ORAC value, antioxidant effects in vivo are probably negligible or absent. [3] [10] By non-antioxidant mechanisms still undefined, flavonoids and other polyphenols may reduce the risk of cardiovascular disease and cancer. [11]
High-dose supplements of antioxidants may be linked to health risks in some cases, including higher mortality rates. For example, high doses of beta-carotene and vitamin E was found to increase the risk of lung cancer and overall mortality in smokers. [2] High doses of vitamin E may increase risks of prostate cancer and one type of stroke.
In terms of cancer prevention, a 2019 study found that participants with the highest intake of lutein and zeaxanthin had the lowest risk of colorectal cancer. Vitamin A Salmon is rich in vitamin A ...
In her further research on cancer chemotherapy, she explored how cisplatin selectively kills proximal tubule cells, identified its metabolic pathway to a nephrotoxin, and showed that the metabolism in these cells is crucial for cisplatin-induced kidney damage, suggesting new targets for inhibition.
“The coffee bean itself has antioxidants in it, which help prevent free radical damage that could potentially lead to cancer,” explains Susan Oh, M.P.H., director of the nutrition research ...
On the contrary, research indicates that although polyphenols are antioxidants in vitro, antioxidant effects in vivo are probably negligible or absent. [3] [4] [5] By non-antioxidant mechanisms still undefined, polyphenols may affect mechanisms of cardiovascular disease or cancer. [6]
Antioxidants are helpful in reducing and preventing damage from free radical reactions because of their ability to donate electrons which neutralize the radical without forming another. Vitamin C , for example, can lose an electron to a free radical and remain stable itself by passing its unstable electron around the antioxidant molecule.
Antioxidants is a peer-reviewed open-access scientific journal that covers various areas of antioxidants research, including biosynthesis, pharmacodynamics, and synthetic antioxidants. It is published by MDPI and was established in 2012. The editor-in-chief is Stanley Omaye (University of Nevada).