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View/Edit Mouse Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene . [ 5 ] [ 6 ] The encoded protein is a transmembrane protein located in the mitochondrial inner membrane and catalyzes the transport of phosphate ions across it for the purpose of oxidative phosphorylation .
A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi.Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. [2]
The mitochondrial unfolded protein response (UPR mt) is a cellular stress response related to the mitochondria. The UPR mt results from unfolded or misfolded proteins in mitochondria beyond the capacity of chaperone proteins to handle them. [1] The UPR mt can occur either in the mitochondrial matrix or in the mitochondrial inner membrane. [1]
Many MC proteins preferentially catalyze the exchange of one solute for another ().A variety of these substrate carrier proteins, which are involved in energy transfer, have been found in the inner membranes of mitochondria and other eukaryotic organelles such as the peroxisome and facilitate the transport of inorganic ions, nucleotides, amino acids, keto acids and cofactors across the membrane.
Mitochondrial DNA is the small circular chromosome found inside mitochondria. These organelles, found in all eukaryotic cells, are the powerhouse of the cell. [1] The mitochondria, and thus mitochondrial DNA, are passed exclusively from mother to offspring through the egg cell.
[4] [44] For example, decreased mitochondrial function has been linked to heart failure and hypertrophy. This mitochondrial response translates into a shift towards glycolysis and lactate production that can cause tumor formation and proliferation of the tissues.
A diagram showing mtDNA (circular) and mitochondrial ribosomes among other mitochondria structures. The mitochondrial ribosome, or mitoribosome, is a protein complex that is active in mitochondria and functions as a riboprotein for translating mitochondrial mRNAs encoded in mtDNA.
View/Edit Mouse Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene . [ 5 ] [ 6 ] This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, [ 7 ] [ 8 ] [ 9 ] and small, round mitochondria. [ 10 ]