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When considering double-stranded DNA, upstream is toward the 5' end of the coding strand for the gene in question and downstream is toward the 3' end. Due to the anti-parallel nature of DNA, this means the 3' end of the template strand is upstream of the gene and the 5' end is downstream.
Upstream extracellular signaling transduce a variety of intracellular cascades. [1] Receptors and ligands are common upstream signaling molecules that dictate the downstream elements of the signal pathway. A plethora of different factors affect which ligands bind to which receptors and the downstream cellular response that they initiate.
As promoters are typically immediately adjacent to the gene in question, positions in the promoter are designated relative to the transcriptional start site, where transcription of DNA begins for a particular gene (i.e., positions upstream are negative numbers counting back from -1, for example -100 is a position 100 base pairs upstream).
A uORF is a coding sequence located in the 5′ UTR located upstream of the coding sequences initiation site. These uORFs contain their own initiation codon, known as an upstream AUG (uAUG). This codon can be scanned for by ribosomes and then translated to create a product, [ 18 ] which can regulate the translation of the main protein coding ...
The upstream and downstream portions must be modeled separately with an initial depth of 9.21 m for the upstream portion, and 0.15 m for the downstream portion. The downstream depth should only be modeled until it reaches the conjugate depth of the normal depth, at which point a hydraulic jump will form.
SnpEff is an open source tool that performs annotation on genetic variants and predicts their effects on genes by using an interval forest approach. This program takes pre-determined variants listed in a data file that contains the nucleotide change and its position and predicts if the variants are deleterious.
A barrage dam can be used to divert water for irrigation needs or limit the amount of water downstream. In most cases, a barrage dam is built near the mouth of the river. The site of dam construction needs to be thoroughly investigated to ensure that the foundation is strong enough to support the dam and has low possibility of failing. [ 2 ]
Therapeutic cell manufacturing processes can be separated into upstream processes and downstream processes. The upstream process is defined as the entire process from early cell isolation and cultivation, to cell banking and culture expansion of the cells until final harvest (termination of the culture and collection of the live cell batch).