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There is growing evidence that psychological stress is a trigger. It can modulate the immune system, causing an increased inflammatory response to allergens and pollutants. [23] Cold weather can make it harder for patients to breathe. [24] Whether high altitude helps or worsens asthma is debatable and may vary from person to person. [25]
AERD affects an estimated 0.3–0.9% of the general population in the US, including around 7% of all asthmatics, about 14% of adults with severe asthma, and ~5-10% of patients with adult onset asthma. [2] [3] [8] AERD is uncommon among children, with around 6% of patients, predominantly female, reporting disease onset during childhood. [9]
Asthma phenotyping and endotyping has emerged as a novel approach to asthma classification inspired by precision medicine which separates the clinical presentations of asthma, or asthma phenotypes, from their underlying causes, or asthma endotypes. The best-supported endotypic distinction is the type 2-high/type 2-low distinction.
Asthma endotyping is useful in predicting which patients will benefit from inhaled corticosteroids or targeted therapy using specific biologics, while phenotyping can help predict disease outcomes. Numerous asthma phenotypes and endotypes have been proposed, though not all have been validated or widely accepted. [1] [2] [3]
Lung restriction in diabetes could result from chronic low-grade tissue inflammation, microangiopathy, and/or accumulation of advanced glycation end products. [46] In fact the presence restrictive lung defect in association with diabetes has been shown even in presence of obstructive lung diseases like asthma and COPD in diabetic patients. [47]
Stillbirth in the week between Christmas and new year, nan passing away 2 weeks after- 2001/2002. Mum passing new years day 2005 Christmas and new year is a s**tty time for me.