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Eflornithine, sold under the brand name Vaniqa among others, is a medication used to treat African trypanosomiasis (sleeping sickness) and excessive hair growth on the face in women. [ 1 ] [ 3 ] [ 4 ] Specifically it is used for the second stage of sleeping sickness caused by T. b. gambiense and may be used with nifurtimox .
Per a May 2015 review, no successful strategy to generate human hair follicles, for hair regrowth, from adult stem cells has yet been reported. [99] However, in April 2016, scientists from Japan published results of their work in which they created human skin from induced pluripotent stem cells ; implanted into laboratory mice, the cells ...
Minoxidil, when applied topically, is used for the treatment of hair loss. [14] It is effective in helping promote hair growth in people with androgenic alopecia regardless of sex. [14] Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth. [6] [7]
Other 5α-reductase inhibitors such as finasteride (a type 2 inhibitor) have been used off-label to treat excessive hair growth in women with hirsutism. [3] [23] Since dutasteride is an inhibitor of both type 1 and 2 5α-reductases, it could theoretically be a more effective therapy for hirsutism. However, dutasteride is not recommended for ...
Flutamide has been researched and used extensively in the treatment of androgen-dependent skin and hair conditions in women including acne, seborrhea, hirsutism, and scalp hair loss, as well as in hyperandrogenism (e.g., in polycystic ovary syndrome or congenital adrenal hyperplasia), and is effective in improving the symptoms of these conditions.
The SULT1A1 enzyme is expressed in outer roots sheath of hair follicles. Minoxidil, the only US FDA approved topical drug for re-growing hair in male and female pattern hair loss (androgenetic alopecia patients) is a pro-drug. Minoxidil is converted to its active form (minoxidil sulfate) by the hair sulfotransferase enzyme (SULT1A1). [6]
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