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The oxygen enhancement ratio (OER) or oxygen enhancement effect in radiobiology refers to the enhancement of therapeutic or detrimental effect of ionizing radiation due to the presence of oxygen. This so-called oxygen effect [1] is most notable when cells are exposed to an ionizing radiation dose.
The best known explanation of the oxygen effect is the oxygen fixation hypothesis developed by Alexander in 1962, [9] which posited that radiation-induced non-restorable or "fixed" nuclear DNA lesions are lethal to cells in the presence of diatomic oxygen. [10] [11] Recent hypotheses include one based on oxygen-enhanced damage from first ...
Oxygen enhancement ratio, effect magnitude of ionizing radiation due to the presence of oxygen; Oxygen Evolution Reaction, the formation of oxygen by electrochemical reduction of water; Owner’s Equivalent Rent, an economic metric for housing prices often used in the calculation of market baskets
As ions' damage is direct, OER (Oxygen Enhancement Ratio) is 1, so the effect of oxygen it is not important. An important approach of hypoxia-related treatment interventions is a procedure called dose painting, in which a higher radiation dose is targeted to hypoxic subvolumes of tumor. [37]
Tumor cells typically have a lower oxygen content than normal tissue. This medical condition is known as tumor hypoxia and therefore the oxygen effect acts to decrease the sensitivity of tumor tissue. [9] The oxygen effect may be quantitatively described by the Oxygen Enhancement Ratio (OER).
Oxygen effect; Oxygen enhancement ratio; P. Pencil-beam scanning; Petkau effect; Potassium iodide; ... This page was last edited on 4 September 2023, at 22:22 (UTC).
The relative biological effectiveness for radiation of type R on a tissue is defined as the ratio R B E = D X D R {\displaystyle RBE={\frac {D_{X}}{D_{R}}}} where D X is a reference absorbed dose of radiation of a standard type X , and D R is the absorbed dose of radiation of type R that causes the same amount of biological damage.
TheraSphere is a radiotherapy treatment for hepatocellular carcinoma (HCC) that consists of millions of microscopic, radioactive glass microspheres (20–30 micrometres in diameter) being infused into the arteries that feed liver tumors.