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Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
Tetracycline hydrochloride is available as yellow crystalline powder. Since tetracycline is absorbed into bone, it is used as a marker of bone growth for biopsies in humans. Tetracycline labeling is used to determine the amount of bone growth within a certain period of time, usually a period around 21 days.
The overall structure of TetR can be broken down into two DNA-binding domains (one per monomer) and a regulatory core, which is responsible for tetracycline recognition and dimerization. TetR dimerizes by making hydrophobic contacts within the regulatory core. There is a binding cavity for tetracycline in the outer helices of the regulatory domain.
Tetracycline-controlled transcriptional activation is a method of inducible gene expression where transcription is reversibly turned on or off in the presence of the antibiotic tetracycline or one of its derivatives (e.g. doxycycline).
Pages in category "Tetracycline antibiotics" The following 20 pages are in this category, out of 20 total. This list may not reflect recent changes. ...
DOGE wants access to filers’ data, and the commerce secretary says Trump wants to scrap the IRS. But filing a return remains mandatory — the earlier the better, tax advisers say.
Tetracycline staining leads to brown bands on the areas of developing enamel. Children up to age 8 can develop mottled enamel from taking tetracycline. As a result, tetracycline is contraindicated in pregnant women. Celiac disease, a disorder characterized by an auto-immune response to gluten, also commonly results in demineralization of the ...
We may receive an affiliate commission from anything you buy from this article. In Bill Gates' new autobiography, "Source Code: My Beginnings" (published February 4 by Knopf), the computer pioneer ...