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Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.
The main mechanisms identified as potential biomarkers of aging are DNA methylation, loss of histones, and histone modification. The uses for biomarkers of aging are ubiquitous and identifying a physical parameter of biological aging would allow humans to determine our true age, mortality, and morbidity. [10]
Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle.
Gerontology (/ ˌ dʒ ɛr ən ˈ t ɒ l ə dʒ i / JERR-ən-TOL-ə-jee) is the study of the social, cultural, psychological, cognitive, and biological aspects of aging.The word was coined by Ilya Ilyich Mechnikov in 1903, from the Greek γέρων (gérōn), meaning "old man", and -λογία (), meaning "study of".
This is an accepted version of this page This is the latest accepted revision, reviewed on 2 February 2025. Biological process of getting older This article is about ageing specifically in humans. For the ageing of whole organisms including animals, see Senescence. For other uses, see Ageing (disambiguation). Part of a series on Human growth and development Stages Gamete Zygote Embryo Fetus ...
GeroScience (formerly Age; Journal of the American Aging Association) is a scientific journal focused on the biology of aging and on mechanistic studies using clinically relevant models of aging and chronic age-related diseases. The journal also publishes articles on health-related aspects of human aging, including biomarkers of aging ...
An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing senescence. They are essentially complications of senescence, distinguished from the aging process itself because all adult animals age ( with rare exceptions ) but not all adult animals ...
Old age is the range of ages for people nearing and surpassing life expectancy. People who are of old age are also referred to as: old people, elderly, elders, senior citizens, seniors or older adults. [1] Old age is not a definite biological stage: the chronological age denoted as "old age" varies culturally and historically. [2]