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During its development for fibromyalgia, milnacipran was evaluated utilizing a composite responder approach.To be considered as a responder for the composite ‘treatment of fibromyalgia’ endpoint, each patient had to show concurrent and clinically meaningful improvements in pain, physical function, and global impression of disease status.
Fibromyalgia as a stand-alone diagnosis is uncommon, as most fibromyalgia patients often have other chronic overlapping pain problems or mental disorders. [11] Fibromyalgia is associated with mental health issues like anxiety , [ 51 ] posttraumatic stress disorder , [ 4 ] [ 51 ] bipolar disorder , [ 51 ] alexithymia , [ 52 ] and depression.
Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, fibromyalgia, neuropathic pain and central sensitization. [10] [11] It is taken by mouth. [10] Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI ...
Over 7,100 bottles of Duloxetine were voluntarily recalled by the medication's company beginning Oct. 10 ... and nerve pain, such as fibromyalgia or ... newsletter to stay up-to-date on the best ...
A 2004 review found benefit for fibromyalgia symptoms, with a reported number needed to treat of 4.8 (meaning that 1 person out of every 4.8 benefits from treatment) for pain reduction, but no change in fatigue or tender points. [36] A 2009 Cochrane review found insufficient evidence to justify its use in myofascial pain syndrome. [37]
The drug is used to treat acute and chronic pain. It has shown effectiveness in the treatment of fibromyalgia, though it is not specifically approved for this purpose. The drug is also under investigation as an antidepressant and for the treatment of neuropathic pain. It is related in chemical structure to venlafaxine.