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Quinine is an alkaloid, a naturally occurring chemical compound. [5] How it works as a medicine is not entirely clear. [5] Quinine was first isolated in 1820 from the bark of a cinchona tree, which is native to Peru, [5] [9] [10] and its molecular formula was determined by Adolph Strecker in 1854. [11]
Restless legs syndrome (RLS), (also known as Willis–Ekbom disease (WED), is a neurological disorder, usually chronic, that causes an overwhelming urge to move one's legs. [2] [10] There is often an unpleasant feeling in the legs that improves temporarily by moving them. [2] This feeling is often described as aching, tingling, or crawling in ...
Quinine is a quinuclidine derivative. Quinuclidine is structurally related to DABCO, in which the other bridgehead is also nitrogen, and to tropane, which has a slightly different carbon frame. Cinchona alkaloids, e.g. quinine, feature quinuclidine substituents. [7] Aceclidine, a simple quinuclidine derivative, is a drug used for treatment of ...
Among the quinoline alkaloids are the cinchona alkaloids quinine and quinidine, which are important due to their therapeutic potential, furthermore cinchonine and cinchonidine, as well as some furoquinoline alkaloids and acridine alkaloids.
The antimalarial drug quinine is a traditional treatment that may be slightly effective for reducing the number of cramps, the intensity of cramps, and the number of days a person experiences cramps. Quinine has not been shown to reduce the duration (length) of a muscle cramp. [6] Quinine treatment may lead to haematologic and cardiac toxicity.
Quinine remained the first-line antimalarial drug of choice until the 1940s, when other drugs replaced it. Until recently Chloroquine was the most widely used antimalarial drug. [ citation needed ] Warburg's Tincture was included in Burroughs Wellcome & Company 's tabloid medicine cases of the late 19th and early 20th centuries.
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