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As with other quinoline antimalarial drugs, the antimalarial mechanism of action of quinine has not been fully resolved. The most accepted model is based on hydrochloroquinine and involves the inhibition of hemozoin biocrystallization, which facilitates the aggregation of cytotoxic heme. Free cytotoxic heme accumulates in the parasites, causing ...
Quinine is a medication used to treat ... Quinine sulfate dihydrate [(quinine ... to use quinine in people with G6PD deficiency when there is no alternative. ...
Hypersensitivity to quinine, mefloquine, quinidine, or dextromethorphan/quinidine with a history of thrombocytopenia, hepatitis, bone marrow depression or lupus-like syndrome induced by these drugs; QT interval, prolonged or congenital long QT syndrome or a history suggesting torsades de pointes
Skraup synthesis using ferrous sulfate, glycerol, aniline, nitrobenzene, and sulfuric acid. A number of other processes exist, which require specifically substituted anilines or related compounds: Camps quinoline synthesis using an o-acylaminoacetophenone and hydroxide; Friedländer synthesis using 2-aminobenzaldehyde and acetaldehyde
Dihydroquinine, also known as hydroquinine [1] or DHQ, is an organic compound and as a cinchona alkaloid closely related to quinine. The specific rotation is −148° in ethanol. A derivative of this molecule is used as chiral ligand in the AD-mix for Sharpless dihydroxylation.
In 1633, this herbal medicine was introduced in Europe, where it was given the same use and also began to be used against malaria. The quinoline antimalarial drug quinine was isolated from the extract in 1820. [49]: 130–131 3-Methylchloroquine (sontochin) After World War I, the German government sought alternatives to quinine.
Quinine, the key ingredient in tonic water, is derived from cinchona bark. It was first used as a digestive aid and later became widely known for its effectiveness in treating malaria.
Dihydroquinidine (also called hydroquinidine) is an organic compound, a cinchona alkaloid closely related to quinine. The specific rotation is +226° in ethanol at 2 g/100 ml. A derivative of this molecule is used as chiral ligand in the AD-mix for Sharpless dihydroxylation. The substance is also a class Ia antiarrhythmic medication. [1]