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From 1996 to 2012, under the trade name Lipitor, atorvastatin became the world's best-selling medication of all time, with more than $125 billion in sales over approximately 14.5 years. [ 117 ] and $13 billion a year at its peak, [ 118 ] Lipitor alone "provided up to a quarter of Pfizer Inc.'s annual revenue for years."
In addition to these interactions atorvastatin and rosuvastatin also form unique hydrogen bonds between Ser 565 residue and either a carbonyl oxygen atom (atorvastatin) or a sulfone oxygen atom (rosuvastatin).
The best-selling statin is atorvastatin, also known as Lipitor, which in 2003 became the best-selling pharmaceutical in history. [12] The manufacturer Pfizer reported sales of US$12.4 billion in 2008. [13] Patient compliance with statin usage is problematic despite robust evidence of the benefits. [14] [15]
A preview of the video premiered on Entertainment Tonight on June 4, 2012. [9] The music video made its world premiere on BET's 106 & Park on June 27, 2012. [10] The music video treatment originally was set to include both Sparks and Houston, But with her unexpected passing in February 2012 before the video was shot the treatment had been ...
Bruce D. Roth is an American organic and medicinal chemist who trained at Saint Joseph's College, Iowa State University and the University of Rochester, and, at the age of 32, discovered atorvastatin, the statin-class drug sold as Lipitor that would become the largest-selling drug in pharmaceutical history (as of 2003).
Still, it’s important to inspect your vitamins closely before taking the plunge. Specifically, if they smell funky, look discolored, or have moisture damage, it’s not worth the risk. “If in ...
On the verge of his 99th birthday, film legend Dick Van Dyke said he's not afraid to die.. The Emmy-winning actor starred in Coldplay's new music video for the track "All My Love," in which Van ...
French Kiss - a half-hour-long block of French language music videos; The Ledge; Loud; Much Alternative; Much Curated By; Much EDM; Much Hip-Hop; Much Mega Hits - an hour-long weekly selection of recent hit videos; Much Now & Then; Much Retro Lunch; Much Spotlight; MuchTopTens; MuchVibe; New.Music.Live; Playlist; Power Shift; The Punk Show ...