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Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]
Older hypotheses such as the Warburg hypothesis suggest the Warburg effect may simply be a consequence of damage to the mitochondria in cancer. It may also be an adaptation to low-oxygen environments within tumors, or a result of cancer genes shutting down the mitochondria, which are involved in the cell's apoptosis program that kills cancer cells.
Lewis Thomas published multiple books throughout his career, the first being The Lives of a Cell: Notes of a Biology Watcher. In 1979 he published The Medusa and the Snail: More Notes of a Biology Watcher. He wrote an autobiographical book in 1983, The Youngest Science: Notes of a Medicine-Watcher.
His book, Life Ascending: The Ten Great Inventions of Evolution, won the 2010 Royal Society Prize for Science Books. [5] He appeared on In Our Time on Radio Four on 13 September 2012, when the topic of discussion was the cell, [6] and again on 15 May 2014, when the topic was photosynthesis.
Mitochondrial DNA has been known to encode 13 proteins. Recently, other short protein coding sequences have been identified, and their products are referred to as mitochondria-derived peptides. [15] The mitochondrial-derived peptide, humanin has been shown to protect against Alzheimer's disease, which is considered an age-associated disease. [16]
Functional mitochondria lead to uninterrupted glycolysis which in turn protects the blebbishields from secondary necrosis. K-Ras , BAD (phosphorylated at Ser-112), p27 , Bax and Bak forms oligomers to boost glycolysis , which in turn overrides secondary necrosis and offer energy required to proceed with the reconstruction process during ...
Azzi has researched the mechanisms through which vitamin E and lycopene prevent prostate cancer and has discovered the transport carrier for aspartic and glutamic acids in mitochondria. [3] He has evaluated vitamin E's roles beyond its antioxidative properties, highlighting its involvement in cellular signaling, gene regulation, and disease ...
Tew co-edited books from the series Advances in Cancer Research alongside Paul B. Fisher, where they provided reviews on diverse cancer research topics. In a review published in the Journal of Medicinal Chemistry, Thomas J. Bardos wrote about the series, "This rapidly growing series of volumes containing many excellent, highly informative, in ...