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Phosphodiesterase enzymes have been shown to be different in different types of cells, including normal and leukemic lymphocytes [11] and are often targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the secondary messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals.
Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5 ′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and calmodulin-dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1-PDE11).
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM] [5]
Check for an entry on the term in the English Wiktionary and its native language Wiktionary, if applicable, to see if it already has an audio pronunciation and/or IPA pronunciation listed. If it has an audio pronunciation, just use that and skip to Add recording to article with IPA below (unless you wish to improve upon it). If you find an ...
PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity, responses to effectors, and regulation mechanism. Most of the PDE families are composed of more than one gene.
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. [4] [5]The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism ...
English. Read; Edit; View history; Tools. Tools. move to sidebar hide. ... cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the ...